Projects

PI: Dr. Ted Clark

Status: Recruiting

Study objectives: To determine whether, in critically ill patients with Acute Kidney Injury requiring renal replacement therapy (AKI-RRT), randomization to receive intravenous hyperoncotic albumin 20-25% (100 mL X two doses) compared to control/placebo normal saline boluses (100 mL X two doses) given during RRT sessions, leads to:

1. An increase in organ support-free days (primary outcome) at 28 days following randomization; and
2. An increase in RRT-free days (principal secondary outcome) at 28 days following randomization.¹

¹https://clinicaltrials.gov/study/NCT04705896

PI: Dr. Justyna Bartoszko

Status: Recruiting

PLTS-1 is a multicentre, randomized, controlled, pilot trial, using a conventional, parallel group, two-armed design at 2 cardiac surgery centres in Canada. The study is designed to assess the feasibility of a future, definitive RCT to determine the non-inferiority of cold-stored platelets compared to conventional platelets with respect to hemostatic effectiveness (total number of allogeneic blood products transfused within 24 hours after CPB), as well as safety.²

²https://clinicaltrials.gov/study/NCT06147531

PI: Dr. Michelle Zeller

Status: In start-up

This trial will study adult patients admitted to the Intensive Care Unit who require an RBC transfusion. Patients will be randomized to receive sex-matched RBCs or sex-mismatched RBCs to determine if there is a difference in mortality between those receiving matched versus mismatched RBCs.³

³https://clinicaltrials.gov/study/NCT06840756

PI: Dr. Jeannie Callum

Status: In start-up

This platform trial will investigate how safe and effective immunoglobulin replacement therapy is compared to oral antibiotics to prevent serious infections in patients with blood cancers, and will also compare different approaches to immunoglobulin dosing to determine the best dose of immunoglobulin for infection prevention. Further comparisons may be added to the platform.⁴

⁴https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=387826&isReview=true

Additional study information:

https://www.rationalisetrial.com/rational-pt

Canadian trial details coming soon!

PI: Dr. Francois LaMontagne

Status: In start-up

Currently, we do not know the platelet count below which giving a platelet transfusion might be beneficial. Surveys of doctors working in UK critical care units have shown uncertainty over the platelet count below which doctors should give a platelet transfusion. As a result, platelet transfusions are currently given to patients with a wide range of different platelet counts and there is no set threshold.

This study will test five different thresholds to find out the safest count below which platelet transfusions should be given before invasive procedures are carried out in intensive care.⁵

⁵https://www.isrctn.com/ISRCTN79371664?q=ISRCTN79371664&filters=&sort=&offset=1&totalResults=1&page=1&pageSize=10

Additional study information:

https://www.icnarc.org/research-studies/t4p/

Canadian trial details coming soon!